Search results for "Estudios Prospectivos"

showing 10 items of 21 documents

Quality of dietary fat intake and body weight and obesity in a Mediterranean population: Secondary analyses within the PREDIMED trial

2018

A moderately high-fat Mediterranean diet does not promote weight gain. This study aimed to investigate the association between dietary intake of specific types of fat and obesity and body weight. A prospective cohort study was performed using data of 6942 participants in the PREDIMED trial, with yearly repeated validated food-frequency questionnaires, and anthropometric outcomes (median follow-up: 4.8 years). The effects of replacing dietary fat subtypes for one another, proteins or carbohydrates were estimated using generalized estimating equations substitution models. Replacement of 5% energy from saturated fatty acids (SFA) with monounsaturated fatty acids (MUFA) or polyunsaturated fatty…

0301 basic medicineMaleMediterranean diethumanosaumento de pesoDiet MediterraneanWeight Gain0302 clinical medicineClinical trialsestudios prospectivosMedicineOily fishProspective StudiesGezondheid en Maatschappijmediana edadDietoteràpiachemistry.chemical_classificationeducation.field_of_studyancianoNutrition and DieteticsMediterranean Regionfood and beveragesMiddle AgedHealth and SocietyRed meatObesitatFemaleDietaBodymedicine.symptomCohort studylcsh:Nutrition. Foods and food supplyPolyunsaturated fatty acidWhite meatPopulation030209 endocrinology & metabolismlcsh:TX341-641Article03 medical and health sciencesgrasas dietéticasAnimal scienceMediterranean cookingOlis i greixos comestiblesCuina mediterràniaHumansObesityeducationVLAGAgedGlobal NutritionWereldvoeding030109 nutrition & dieteticsModels Statisticalbusiness.industryBody WeightDiet therapypeso corporalBody weightmedicine.diseaseWeightObesityDietary FatsDietSubstitution modelschemistryFatEdible oils and fatsbusinessWeight gainFood ScienceAssaigs clínics
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Plasma Metabolites From Choline Pathway and Risk of Cardiovascular Disease in the PREDIMED (Prevention With Mediterranean Diet) Study.

2017

Background-The relationship between plasma concentrations of betaine and choline metabolism and major cardiovascular disease (CVD) end points remains unclear. We have evaluated the association between metabolites from the choline pathway and risk of incident CVD and the potential modifying effect of Mediterranean diet interventions. Methods and Results-We designed a case-cohort study nested within the PREDIMED (Prevention With Mediterranean Diet) trial, including 229 incident CVD cases and 751 randomly selected participants at baseline, followed up for 4.8 years. We used liquid chromatography-tandem mass spectrometry to measure, at baseline and at 1 year of follow-up, plasma concentrations …

0301 basic medicineMaleTime FactorsMediterranean dietEpidemiologymodelos de riesgos proporcionaleshumanosSistema cardiovascular -- Malaltieséteres de fosfolípidosDisease030204 cardiovascular system & hematologyGut floraDiet MediterraneanCholinechemistry.chemical_compound0302 clinical medicineBetainecardiovascular diseaseRisk FactorsTandem Mass Spectrometryestudios prospectivosmetabolómicaCholineProspective StudiesTrimethylamine-n-oxidemediana edadOriginal ResearchDiet and Nutritionmetilaminas2. Zero hungerAged 80 and overChromatographyancianoCholine metabolismbiologydietaresultado del tratamientoIncidencePhospholipid Ethersdistribución de la ji al cuadradoMiddle AgedCardiovascular disease3. Good healthPrimary PreventioncolinaTreatment OutcomeCardiovascular Diseasesespectrometría de masas en tándemPlasma concentrationProfileFemaleCardiology and Cardiovascular Medicinefosforilcolinamedicine.medical_specialtyPhosphorylcholineestudios de casos y controlesenfermedades cardiovascularesGut microbiotaincidencia03 medical and health sciencesMethylaminesfactores de tiempoInternal medicineMediterranean dietOxidationmedicinefactores de riesgoHumansMetabolomicsanálisis multifactorialDieta -- Mediterrània Regió de lacromatografíaAgedProportional Hazards ModelsChi-Square Distributiongut microbiotabusiness.industrybetaínaPlasma sanguiniLifestylebiology.organism_classificationPredimedDietBetainePhosphatidylcholine030104 developmental biologyEndocrinologychemistrySpainCase-Control StudiesMultivariate AnalysisbusinessBiomarkersChromatography Liquid
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Detection of MET Alterations Using Cell Free DNA and Circulating Tumor Cells from Cancer Patients

2020

MET alterations may provide a potential biomarker to evaluate patients who will benefit from treatment with MET inhibitors. Therefore, the purpose of the present study is to investigate the utility of a liquid biopsy-based strategy to assess MET alterations in cancer patients. We analyzed MET amplification in circulating free DNA (cfDNA) from 174 patients with cancer and 49 healthy controls and demonstrated the accuracy of the analysis to detect its alteration in patients. Importantly, a significant correlation between cfDNA concentration and MET copy number (CN) in cancer patients (r = 0.57, p &lt

0301 basic medicineOncologyMale<i>MET</i> copy numbermedicine.medical_treatmentproteínas protooncogénicas c-metdosificación génicahumanosresistencia a medicamentosDrug ResistanceGene Dosagecirculating free DNA (cfDNA)<i>MET</i> amplificationTargeted therapyTargeted therapy0302 clinical medicineCirculating tumor cellestudios prospectivosNeoplasmsantineoplásicosProspective Studieslcsh:QH301-705.5Circulating tumor cells (CTCs)neoplasiasGeneral MedicineProto-Oncogene Proteins c-mettargeted therapyNeoplastic Cells CirculatingErbB ReceptorsCell-free fetal DNA030220 oncology & carcinogenesisinhibidores de proteína cinasasBiomarker (medicine)FemaleMET protein expressionCell-Free Nucleic AcidsMET amplificationmedicine.medical_specialtycirculating tumor cells (CTCs)estudios de casos y controlesMet amplificationCirculating free DNA (cfDNA)Antineoplastic AgentsArticle03 medical and health sciencesInternal medicinemedicineBiomarkers TumorHumansLiquid biopsyProtein Kinase InhibitorsRetrospective Studiesbusiness.industryHead and neck cancerestudios retrospectivosLiquid BiopsyCancermedicine.disease030104 developmental biologylcsh:Biology (General)Drug Resistance NeoplasmCase-Control StudiesMET copy numberbusinessCells
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Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis o…

2018

Background: Diabetes mellitus is a common co-existing disease in the critically ill. Diabetes mellitus may reduce the risk of acute respiratory distress syndrome (ARDS), but data from previous studies are conflicting. The objective of this study was to evaluate associations between pre-existing diabetes mellitus and ARDS in critically ill patients with acute hypoxemic respiratory failure (AHRF). Methods: An ancillary analysis of a global, multi-centre prospective observational study (LUNG SAFE) was undertaken. LUNG SAFE evaluated all patients admitted to an intensive care unit (ICU) over a 4-week period, that required mechanical ventilation and met AHRF criteria. Patients who had their AHRF…

AdultMaleDiabetes mellituLUNG SAFEOrgan Dysfunction Scoreshumanoslnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]Socio-culturaleOrgan Dysfunction ScoreDiabetes ComplicationsDiabetes mellituspuntuaciones de disfunción orgánicaRisk FactorsDiabetes Complicationestudios prospectivosHumansfactores de riesgoProspective StudiesHospital MortalityHypoxiamediana edadAcute hypoxemic respiratory failureAgedRespiratory Distress SyndromeancianoAcute respiratory distress syndromeResearchRespirationrespiraciónRespiratory Distress Syndrome Adultlcsh:Medical emergencies. Critical care. Intensive care. First aidlcsh:RC86-88.9Middle AgedRespiration Artificialinsuficiencia respiratoriaAcute hypoxemic respiratory failure; Acute respiratory distress syndrome; Diabetes mellitus; LUNG SAFEProspective StudieArtificialAcute hypoxemic respiratory failure; Acute respiratory distress syndrome; Diabetes mellitus; LUNG SAFE; Aged; Diabetes Complications; Diabetes Mellitus; Female; Hospital Mortality; Humans; Hypoxia; Male; Middle Aged; Organ Dysfunction Scores; Prospective Studies; Respiration Artificial; Respiratory Distress Syndrome Adult; Respiratory Insufficiency; Risk FactorsFemaleRespiratory Insufficiencymortalidad hospitalariacomplicaciones de la diabetesHuman
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Pooled analysis of who surgical safety checklist use and mortality after emergency laparotomy

2019

Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients incl…

AdultMalebarriershumanoschecklist; surgery; human development indexGlobalSurg CollaborativeWHO Surgical Safety Checklist mortality emergency laparotomyWorld Health Organizationseguridad del pacienteNOCohort Studieslista de controlestudios prospectivosHumanstasa de supervivenciaProspective Studiesimplementationestudios de cohortesSurgery; implementation; health; barriersEmergency Treatment11 Medical and Health Sciencesmediana edadDigestive System Surgical ProceduresAgedancianoLaparotomyScience & TechnologyhealthOriginal ArticlesadultoMiddle Agedchecklist WHOprocedimientos quirúrgicos del sistema digestivoChecklistSurvival RateElective Surgical Procedureslaparotomíatratamiento de urgenciaSurgeryOriginal ArticleFemalePatient SafetyLife Sciences & Biomedicine
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Antilymphocyte Globulin for Prevention of Chronic Graft-versus-Host Disease.

2016

Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; BACKGROUND Chronic graft-versus-host disease (GVHD) is the leading cause of later illness and death after allogeneic hematopoietic stem-cell transplantation. We hypothesized that the inclusion of antihuman T-lymphocyte immune globulin (ATG) in a myeloablative conditioning regimen for patients with acute leukemia would result in a significant reduction in chronic GVHD 2 years after allogeneic peripheral-blood stem-cell transplantation from an HLA-identical sibling. METHODS We conducted a prospective, multicenter, open-label, randomized phase 3 study of ATG as part of …

Male:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models Statistical::Proportional Hazards Models [Medical Subject Headings]T-LymphocytesPhases of clinical researchGraft vs Host Disease:Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings]Linfocitos t:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Immunosuppressive Agent0302 clinical medicineTrasplante homólogoEstudios prospectivosMedicineCumulative incidenceProspective StudiesProspective cohort studyChildTransplantation Homologou:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Immune Sera::Antilymphocyte Serum [Medical Subject Headings]Acute leukemia:Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes Mononuclear::Lymphocytes::T-Lymphocytes [Medical Subject Headings]:Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Disease Attributes::Chronic Disease [Medical Subject Headings]:Named Groups::Persons::Age Groups::Child::Child Preschool [Medical Subject Headings]Medicine (all)IncidenceSuero antilinfocíticoGeneral MedicineMiddle AgedModelos de riesgos proporcionales3. Good healthHumanosSurvival Rate030220 oncology & carcinogenesis:Named Groups::Persons::Age Groups::Adolescent [Medical Subject Headings]Child PreschoolFemale:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Immunologic Factors::Immunosuppressive Agents [Medical Subject Headings]Immunosuppressive AgentsHumanHomologousAdultmedicine.medical_specialty:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies [Medical Subject Headings]:Named Groups::Persons::Age Groups::Adult::Young Adult [Medical Subject Headings]AdolescentEnfermedad injerto contra huéspedDisease-Free Survival03 medical and health sciencesYoung AdultInternal medicine:Named Groups::Persons::Age Groups::Adult [Medical Subject Headings]HumansTransplantation HomologousSupervivencia sin enfermedadPreschoolSurvival rate:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Disease-Free Survival [Medical Subject Headings]:Named Groups::Persons::Age Groups::Child [Medical Subject Headings]Antilymphocyte SerumProportional Hazards ModelsTransplantationbusiness.industryEnfermedad crónicamedicine.diseaseInmunosupresoresAnti-thymocyte globulinSurgeryTransplantation:Diseases::Immune System Diseases::Graft vs Host Disease [Medical Subject Headings]Prospective Studie:Analytical Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures Operative::Transplantation::Transplantation Homologous [Medical Subject Headings]Graft-versus-host diseaseT-Lymphocyte:Check Tags::Female [Medical Subject Headings]Chronic DiseaseProportional Hazards ModelAdolescent; Adult; Antilymphocyte Serum; Child; Child Preschool; Chronic Disease; Disease-Free Survival; Female; Graft vs Host Disease; Humans; Immunosuppressive Agents; Incidence; Male; Middle Aged; Proportional Hazards Models; Prospective Studies; Survival Rate; T-Lymphocytes; Transplantation Homologous; Young Adult; Medicine (all)business030215 immunology
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Epidemiology and patterns of tracheostomy practice in patients with acute respiratory distress syndrome in ICUs across 50 countries

2018

Background: To better understand the epidemiology and patterns of tracheostomy practice for patients with acute respiratory distress syndrome (ARDS), we investigated the current usage of tracheostomy in patients with ARDS recruited into the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG-SAFE) study. Methods: This is a secondary analysis of LUNG-SAFE, an international, multicenter, prospective cohort study of patients receiving invasive or noninvasive ventilation in 50 countries spanning 5 continents. The study was carried out over 4 weeks consecutively in the winter of 2014, and 459 ICUs participated. We evaluated the clinical characteris…

MaleARDSInternationality[SDV]Life Sciences [q-bio]humanoslnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]traqueostomíaCritical Care and Intensive Care MedicineSeverity of Illness IndexCohort StudiesPropensity-matched analysi0302 clinical medicineTracheostomyestudios prospectivosEpidemiologyAcute respiratory distress syndrome (ARDS)030212 general & internal medicineProspective Studiespuntuación de propensión10. No inequalityProspective cohort studyestudios de cohortesmediana edadancianoRespiratory Distress SyndromerespiraciónRespirationlcsh:Medical emergencies. Critical care. Intensive care. First aidMiddle Aged3. Good healthIntensive Care UnitsCohortArtificialCritical IllneFemaleAcute respiratory distress syndrome (ARDS); ICU; Propensity-matched analysis; Tracheostomy; Ventilation; Aged; Cohort Studies; Critical Illness; Female; Humans; Intensive Care Units; Internationality; Male; Middle Aged; Propensity Score; Prospective Studies; Respiration Artificial; Respiratory Distress Syndrome Adult; Severity of Illness Index; TracheostomyCohort studyHumanAdultmedicine.medical_specialtyCritical IllnessIntensive Care UnitSocio-culturaleunidades de cuidados intensivosenfermedad críticaPropensity-matched analysis03 medical and health sciencesAcute respiratory distress syndrome (ARDS); ICU; Propensity-matched analysis; Tracheostomy; VentilationSeverity of illnessSettore MED/41 - ANESTESIOLOGIAmedicineHumansíndice de gravedad de la enfermedadPropensity ScoreAgedbusiness.industryResearchRespiratory Distress Syndrome Adultinternacionalidadlcsh:RC86-88.9medicine.diseaseR1Respiration ArtificialVentilationProspective Studie030228 respiratory systemPropensity score matchingEmergency medicineICUObservational studyCohort Studiebusiness
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Immunocompromised patients with acute respiratory distress syndrome: Secondary analysis of the LUNG SAFE database

2018

Background: The aim of this study was to describe data on epidemiology, ventilatory management, and outcome of acute respiratory distress syndrome (ARDS) in immunocompromised patients. Methods: We performed a post hoc analysis on the cohort of immunocompromised patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) study. The LUNG SAFE study was an international, prospective study including hypoxemic patients in 459 ICUs from 50 countries across 5 continents. Results: Of 2813 patients with ARDS, 584 (20.8%) were immunocompromised, 38.9% of whom had an unspecified cause. Pneumonia, nonpulmonary sepsis, and noncardiog…

MaleARDSmodelos logísticosDatabases Factualmedicine.medical_treatment[SDV]Life Sciences [q-bio]humanoslnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]Kaplan-Meier EstimateCritical Care and Intensive Care MedicineAcute respiratory failureSeverity of Illness IndexCohort Studiesrandomized-trial0302 clinical medicineMechanical ventilationRisk Factorsestudios prospectivosEpidemiology80 and overicuMedicineProspective StudiesProspective cohort studyestudios de cohortesImmunodeficiencymediana edadestadísticasAged 80 and overRespiratory Distress Syndromeancianocritically-ill patientsRespirationresultado del tratamientorespiraciónStatisticslcsh:Medical emergencies. Critical care. Intensive care. First aidadultoMiddle Aged3. Good healthfailureIntensive Care UnitsTreatment OutcomeArtificialCohortprospective multicenterImmunocompromised patientsAcute respiratory failure; ARDS; Immunocompromised patients; Mechanical ventilation; Noninvasive ventilation; Critical Care and Intensive Care MedicineFemaleNoninvasive ventilationHumanestimación de Kaplan-MeierAdultmedicine.medical_specialtyLogistic ModelIntensive Care UnitSocio-culturaleunidades de cuidados intensivossurvivalStatistics NonparametricSepsisDatabases03 medical and health sciencesImmunocompromised HostInternal medicineImmunocompromised patientcancerfactores de riesgoHumansNonparametricíndice de gravedad de la enfermedadintensive-care-unitFactualAgedMechanical ventilationbusiness.industryResearchRisk FactorRespiratory Distress Syndrome Adult030208 emergency & critical care medicinelcsh:RC86-88.9medicine.diseaseRespiration ArtificialPneumoniaProspective StudieLogistic Models030228 respiratory systemmalignanciesARDShuésped inmunodeprimidoCohort StudiebusinessAcute respiratory failure; ARDS; Immunocompromised patients; Mechanical ventilation; Noninvasive ventilation; Adult; Aged; Aged 80 and over; Cohort Studies; Databases Factual; Female; Humans; Intensive Care Units; Kaplan-Meier Estimate; Logistic Models; Male; Middle Aged; Prospective Studies; Respiration Artificial; Respiratory Distress Syndrome Adult; Risk Factors; Severity of Illness Index; Statistics Nonparametric; Treatment Outcome; Immunocompromised Host
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The Role of Neuroticism in Predicting Psychological Harassment in Nursing: A Longitudinal Study

2019

Psychological harassment is a serious occupational risk for nurses, but little is known about its related factors and possible predictors. The objective of the present study was to investigate whether nursing students&rsquo

MaleAdult050103 clinical psychologyLongitudinal studyCoping (psychology)emocionesOccupational riskHealth Toxicology and MutagenesisEmotionshumanosPsychological interventionlcsh:MedicineNursing Staff HospitalStructural equation modelingArticle03 medical and health sciencesYoung AdultNursingnursingOccupational Exposureestudios prospectivosAdaptation PsychologicalHumans0501 psychology and cognitive sciencesProspective StudiesLongitudinal StudiesneuroticismOccupational Healthmediana edad030504 nursingemotional coping05 social scienceslcsh:RPublic Health Environmental and Occupational HealthharassmentMiddle AgedadultoNeuroticismadulto jovenpersonalityTraitHarassmentestudios longitudinalesFemaleHarassment Non-Sexualbehavioral coping0305 other medical sciencePsychologyStress PsychologicalInternational Journal of Environmental Research and Public Health
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Dietary α-Linolenic Acid, Marine ω-3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvención con DIeta ME…

2016

12 Páginas.-- 6 Tablas.-- 1 Figura

MaleGerontologyTime FactorsEpidemiologymodelos de riesgos proporcionaleshumanos030204 cardiovascular system & hematologychemistry.chemical_compound0302 clinical medicineRisk Factorsestudios prospectivosevaluación de riesgosMedicineNutsSudden cardian death030212 general & internal medicineFood scienceLongitudinal StudiesProspective Studiesmediana edadOriginal ResearchDiet and NutritionAged 80 and overchemistry.chemical_classificationeducation.field_of_studyancianoalpha-Linolenic aciddietaFactors de risc en les malaltiesHàbits alimentarisFatty Acidsω-3 fatty acidsFatty acids in human nutritionalpha-Linolenic Aciddistribución de la ji al cuadradoMiddle AgedCardiovascular systemnutritionCardiovascular DiseasesFemaleDietaCardiology and Cardiovascular MedicineNutritive Valueconducta de reducción del riesgoRisk factors in diseasesFood habitsPopulationenfermedades cardiovasculares030209 endocrinology & metabolismJuglansRisk Assessmentsudden cardiac death03 medical and health sciencesalimentos del marfactores de tiempoMediterranean cookingÀcids grassos en la nutricióFatty Acids Omega-3Cuina mediterràniaPeix com a alimentHumansfactores de riesgoanálisis multifactorialeducationOlive OilDieta -- Mediterrània Regió de laDieta mediterraneaácidos grasosα-linolenic acidAgedProportional Hazards ModelsSistema cardiovascularChi-Square Distributionbusiness.industryCorrectionFatty acidHàbits alimentaris -- Mediterrània Regió de laProtective FactorsFish consumptionPredimedDietnueceschemistrySeafoodSpainMultivariate Analysisvalor nutritivoestudios longitudinalesfatty acidbusinessRisk Reduction Behaviorácido alfa-linolénico
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